Mastr^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Mastr^C57BL/6J
• Name: modifier of astrocytoma; C57BL/6J
• MGI ID: MGI:3587057
• QTL: Mastr Location: Chr11:45708581-89818733 bp Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers astrocytoma susceptibility compared to 129S4/SvJae. (J:92444)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:92444

Susceptibility to astrocytoma was investigated in NPcis mice on a C57BL/6J background. NPcix are informative because they carry alleles which modify the effects of mutant Nf1 and Trp53 genes in the development of astrocytoma which is similar to strain 129S4/SvJae. A region between D11Mit271 and D11Mit285 was indicated as including genes which may have a modifying effect on the progression of astrocytoma. SNP analysis showed as many as 41 potential candidate genes within the Mastr region.

References

• Original: J:92444 Reilly KM, et al., Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13008-13
• All: 1 reference(s)