mdlk1^MOLF/Ei
QTL Variant Detail

Summary

• QTL variant: mdlk1^MOLF/Ei
• Name: modifier of Dlk1; MOLF/Ei
• MGI ID: MGI:3587061
• QTL: mdlk1 Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 15.86 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: MOLF/Ei

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased reactivation of imprinted gene Dlk1 compared to C57BL/6J. (J:97841)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:97841

MOLF/Ei mice were analysed to show that a number of modifier loci in that strain may effect the expression of mouse Chromosome 12 gene Dlk1. Matings of MOLF/Ei and C57BL/6J were informative in mapping one such modifier mdlk1 within a region of mouse Chromosome 7 that included markers D7Mit57, D7Mit294 and D7Mit267. For the purpose of placing mdlk1 on the genetic map MGI will use the cM assignment of D7Mit294 for mdlk1.

References

• Original: J:97841 Croteau S, et al., Increased plasticity of genomic imprinting of Dlk1 in brain is due to genetic and epigenetic factors. Mamm Genome. 2005 Feb;16(2):127-35
• All: 1 reference(s)