Hjv^tm1Nca
Targeted Allele Detail

Summary

• Symbol: Hjv^tm1Nca
• Name: hemojuvelin BMP co-receptor; targeted mutation 1, Nancy C Andrews
• MGI ID: MGI:3587746
• Synonyms: Hfe2^-, Hjv^-
• Gene: Hjv Location: Chr3:96432488-96436526 bp, + strand Genetic Position: Chr3, 41.91 cM
• Alliance: Hjv^tm1Nca page

Histological examination of iron loading in Hjv^tm1Nca/Hjv^tm1Nca mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100178
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 and the coding sequence in exon 4 were replaced upon the insertion of a floxed neo cassette, therefore deleting most of the coding sequence for the protein. (J:100178)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hjv Mutation: 19 strains or lines available

References

• Original: J:100178 Huang FW, et al., A mouse model of juvenile hemochromatosis. J Clin Invest. 2005 Aug 1;115(8):2187-2191
• All: 29 reference(s)