Hjv^tm1Arbr
Targeted Allele Detail

Summary

• Symbol: Hjv^tm1Arbr
• Name: hemojuvelin BMP co-receptor; targeted mutation 1, Silvia Arber
• MGI ID: MGI:3587747
• Synonyms: Hjv^-
• Gene: Hjv Location: Chr3:96432488-96436526 bp, + strand Genetic Position: Chr3, 41.91 cM
• Alliance: Hjv^tm1Arbr page

Iron accumulation in Hjv^tm1Arbr/Hjv^tm1Arbr mutant mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100173
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting construct containing eGFP followed by IRES-NLS-lacZ-pA and thymidine kinase-neomycin (TK-neo) cassettes was integrated in frame into the second coding exon. (J:100173)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hjv Mutation: 19 strains or lines available

References

• Original: J:100173 Niederkofler V, et al., Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest. 2005 Aug;115(8):2180-6
• All: 5 reference(s)