Myo1a^tm1Mtys
Targeted Allele Detail

Summary

• Symbol: Myo1a^tm1Mtys
• Name: myosin IA; targeted mutation 1, Matthew J Tyska
• MGI ID: MGI:3587749
• Gene: Myo1a Location: Chr10:127541039-127556809 bp, + strand Genetic Position: Chr10, 74.62 cM
• Alliance: Myo1a^tm1Mtys page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100193
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo/ura3 cassette replaced the first three exons. Absence of protein in mutants was confirmed by immunoblot of small intestines. Immunostaining of mutant duodenal sections with an antibody directed against the TH1 domain showed the expected lack of signal in mutants. (J:100193)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myo1a Mutation: 62 strains or lines available

References

• Original: J:100193 Tyska MJ, et al., Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell. 2005 May;16(5):2443-57
• All: 5 reference(s)