Cxadr^tm1Dvst
Targeted Allele Detail

Summary

• Symbol: Cxadr^tm1Dvst
• Name: coxsackie virus and adenovirus receptor; targeted mutation 1, Dietmar Vestweber
• MGI ID: MGI:3587803
• Synonyms: CAR^-
• Gene: Cxadr Location: Chr16:78098377-78156662 bp, + strand Genetic Position: Chr16, 45.28 cM, cytoband C
• Alliance: Cxadr^tm1Dvst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100174
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1, which contains the ATG start codon. Western blot of embryos failed to detect protein in mutants. (J:100174)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxadr Mutation: 15 strains or lines available

References

• Original: J:100174 Dorner AA, et al., Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development. J Cell Sci. 2005 Aug 1;118(Pt 15):3509-21
• All: 1 reference(s)