Tes^tm1Cro
Targeted Allele Detail

Summary

• Symbol: Tes^tm1Cro
• Name: testin LIM domain protein; targeted mutation 1, Carlo M Croce
• MGI ID: MGI:3587810
• Synonyms: TES^-
• Gene: Tes Location: Chr6:17065148-17105824 bp, + strand Genetic Position: Chr6, 7.67 cM
• Alliance: Tes^tm1Cro page

Histopathology and cell proliferation in forestomach of Tes^tm1Cro/Tes⁺ and Tes^tm1Cro/Tes^tm1Cro mice on a zinc deficient diet

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100181
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 3. Mutants produced two aberrant transcripts in which the first half of exon 3 was deleted. Western blot revealed that these transcripts were not translated into protein. (J:100181)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tes Mutation: 32 strains or lines available

References

• Original: J:100181 Drusco A, et al., Knockout mice reveal a tumor suppressor function for Testin. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10947-51
• All: 2 reference(s)