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Sluc4B10.O20/Dem
QTL Variant Detail
Summary
QTL variant: Sluc4B10.O20/Dem
Name: susceptibility to lung cancer 4; B10.O20/Dem
MGI ID: MGI:3587855
QTL: Sluc4  Location: unknown  Genetic Position: Chr11, cM position of peak correlated region/allele: 42.94 cM
Variant
origin
Strain of Specimen:  B10.O20/Dem
Variant
description
Allele Type:    QTL
Inheritance:    Other (see notes)
Notes
Susceptibility/resistance to lung tumors depends upon interactive effects involving Sluc3 and Sluc4.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:36997

Lung tissue of N-ethyl-N-nitrosourea treated F2 progeny of an (OcB-9/Dem x O20/A)F1 intercross was microscopically analyzed for the presence and size of tumors. The progeny were genotyped by PCR. Statistical analysis indicated the presence of a locus influencing susceptibility to lung cancer (Sluc4) on mouse Chromosome 11. The QTL likelihood plot indicates a peak near D11Mit15. The following order of loci was reported: D11Mit15 - Sluc4 - D11Mit41 - Rara.

References
Original:  J:36997 Fijneman RJ, et al., Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse. Nat Genet. 1996 Dec;14(4):465-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory