Tlsr7^MSM
QTL Variant Detail

Summary

• QTL variant: Tlsr7^MSM
• Name: thymic lymphoma suppressor region 7; MSM
• MGI ID: MGI:3587860
• QTL: Tlsr7 Location: unknown Genetic Position: Chr16, cM position of peak correlated region/allele: 3.39 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: MSM

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:48036

The authors were attempting to fine map regions of mouse chromosomes that exhibited allelic loss in gamma ray-induced-lymphomas in (BALB/c x MSM)F1 x MSM or (BALB/c c MSM)F1 x BALB/c backcross mice. A region of mouse Chromosome 16 in the vicinity of D16Mit122 (3.85 cM) showed a high frequency of allelic loss. This region is given the symbol Tlsr7. (The authors identified this region as TLSR16a). Allelic loss at Tlsr7 shows strong association with the Trp53^tm1Sia allele. Scid (9.9 cM) is a potential candidate gene for Tlsr7 but allelic loss at Scid in lymphomas is less than allelic loss at Tlsr7. A previously identified radiation-induced apoptosis QTL named Rapop1 (22.2 cM) maps near Tlsr7.

References

• Original: J:48036 Matsumoto Y, et al., Allelic loss analysis of gamma-ray-induced mouse thymic lymphomas: two candidate tumor suppressor gene loci on chromosomes 12 and 16. Oncogene. 1998 May 28;16(21):2747-54
• All: 1 reference(s)