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W3q15L6
QTL Variant Detail
Summary
QTL variant: W3q15L6
Name: weight 3 weeks QTL 15; L6
MGI ID: MGI:3587865
QTL: W3q15  Location: Chr18:5041119-61272643 bp  Genetic Position: Chr18, Syntenic
Variant
origin
Strain of Specimen:  L6
Variant
description
Allele Type:    QTL
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87794

More than 1000 animals from an (M16i x L6)F2 intercross were typed for 63 polymorphic markers over 19 autosomes to identify QTLs associated with growth traits. Body weight was measured at 21, 42, and 70 days of age. Tail length was measured at 70 days asan indicator of skeletal growth. Parental strain M16i exhibits high weight gain between 21 and 42 days of age while parental strain L6 exhibits low weight gain. LOD=3.3 was used as the cutoff for statistically significant linkage.

W3q15 mapped to an interval on mouse Chromosome 18 between D18Mit19 and D18Mit51. W3q15 peaks at 29.4 cM (LOD=3.7) and the QTL interval spans 15.7 cM - 37 cM. M16i-derived alleles confer increased 3 week body weight with a dominant mode of inheritance. This locus explains 1.6% of the variance.

W3q16 mapped to an interval between D18Mit51 and D18Mit3. W3q16 peaks at 39.4 cM (LOD=3.6) and the QTL interval spans 37 cM - 46 cM. M16i-derived alleles confer increased body weight at 3 weeks of age with a dominant mode of inheritance. This locus explains 1.3% of the variance.

References
Original:  J:87794 Rocha JL, et al., A large-sample QTL study in mice: I. Growth. Mamm Genome. 2004 Feb;15(2):83-99
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory