W3q15^M16i
QTL Variant Detail

Summary

• QTL variant: W3q15^M16i
• Name: weight 3 weeks QTL 15; M16i
• MGI ID: MGI:3587866
• QTL: W3q15 Location: Chr18:5041119-61272643 bp Genetic Position: Chr18, Syntenic

Variant origin

• Strain of Specimen: M16i

Variant description

• Allele Type: QTL
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87794

More than 1000 animals from an (M16i x L6)F2 intercross were typed for 63 polymorphic markers over 19 autosomes to identify QTLs associated with growth traits. Body weight was measured at 21, 42, and 70 days of age. Tail length was measured at 70 days asan indicator of skeletal growth. Parental strain M16i exhibits high weight gain between 21 and 42 days of age while parental strain L6 exhibits low weight gain. LOD=3.3 was used as the cutoff for statistically significant linkage.

W3q15 mapped to an interval on mouse Chromosome 18 between D18Mit19 and D18Mit51. W3q15 peaks at 29.4 cM (LOD=3.7) and the QTL interval spans 15.7 cM - 37 cM. M16i-derived alleles confer increased 3 week body weight with a dominant mode of inheritance. This locus explains 1.6% of the variance.

W3q16 mapped to an interval between D18Mit51 and D18Mit3. W3q16 peaks at 39.4 cM (LOD=3.6) and the QTL interval spans 37 cM - 46 cM. M16i-derived alleles confer increased body weight at 3 weeks of age with a dominant mode of inheritance. This locus explains 1.3% of the variance.

References

• Original: J:87794 Rocha JL, et al., A large-sample QTL study in mice: I. Growth. Mamm Genome. 2004 Feb;15(2):83-99
• All: 1 reference(s)