W3q14^M16i
QTL Variant Detail

Summary

• QTL variant: W3q14^M16i
• Name: weight 3 weeks QTL 14; M16i
• MGI ID: MGI:3587872
• QTL: W3q14 Location: Chr19:22313326-53911504 bp Genetic Position: Chr19, Syntenic

Variant origin

• Strain of Specimen: M16i

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body weight at 3 weeks compared to L6. (J:87794)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

W3q14 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87794

More than 1000 animals from an (M16i x L6)F2 intercross were typed for 63 polymorphic markers over 19 autosomes to identify QTLs associated with growth traits. Body weight was measured at 21, 42, and 70 days of age. Tail length was measured at 70 days asan indicator of skeletal growth. Parental strain M16i exhibits high weight gain between 21 and 42 days of age while parental strain L6 exhibits low weight gain. LOD=3.3 was used as the cutoff for statistically significant linkage.

W3q14 mapped to an interval on mouse Chromosome 19 between D19Mit45 and D19Mit36. W3q14 peaks at 36.3 cM (LOD=3.7) and M16i-derived alleles confer increased 3 week body weight with an additive mode of inheritance. This locus explains 0.8% of the variance.

References

• Original: J:87794 Rocha JL, et al., A large-sample QTL study in mice: I. Growth. Mamm Genome. 2004 Feb;15(2):83-99
• All: 1 reference(s)