Itpk1^{Gt(DTM066)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Itpk1^{Gt(DTM066)Byg}
• Name: inositol 1,3,4-triphosphate 5/6 kinase; gene trap DTM066, BayGenomics
• MGI ID: MGI:3587933
• Synonyms: Itpk1^{Gt(pGT1dTMpfs)1Ucd}
• Gene: Itpk1 Location: Chr12:102534842-102671128 bp, - strand Genetic Position: Chr12, 51.69 cM
• Alliance: Itpk1^{Gt(DTM066)Byg} page

Nueral tube defects and axial skeleton malformations in Itpk1^{Gt(DTM066)Byg}/Itpk1^{Gt(DTM066)Byg} mouse embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: DTM066
• Germline Transmission: Earliest citation of germline transmission: J:150075
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1dTMpfs Vector Type: secretory trap
• Mutation details: The gene trap vector pGT1dTMpfs, which contains a beta-geo cassette, inserted downstream of exon 2. This allele is predicted to be hypomorphic. (J:150075)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  DTM066	CC156129 ; (MGI Seq Detail)	5' RACE	Chr12:102641701-102671127 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  135 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itpk1 Mutation: 152 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:150075 Wilson MP, et al., Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9831-5
• All: 2 reference(s)