Npc2^{Gt(LST105)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Npc2^{Gt(LST105)Byg}
• Name: NPC intracellular cholesterol transporter 2; gene trap LST105, BayGenomics
• MGI ID: MGI:3587940
• Synonyms: Npc2^{Gt(pGT1TMpfs)1Ucd}, Npc2^{Gt(pGT1TMpfs)1Ucd.Mmc}
• Gene: Npc2 Location: Chr12:84801333-84819886 bp, - strand Genetic Position: Chr12, 39.37 cM
• Alliance: Npc2^{Gt(LST105)Byg} page

Mutation origin

• Mutant Cell Line: LST105
• Germline Transmission: Earliest citation of germline transmission: J:125609
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1TMpfs Vector Type: secretory trap
• No molecular information is available.
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  LST105	CC156347 ; (MGI Seq Detail)	5' RACE	Chr12:84819559-84819730 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  14 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npc2 Mutation: 23 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:125609 Schrantz N, et al., The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells. J Exp Med. 2007 Apr 16;204(4):841-52
• All: 4 reference(s)