Pdzk1^tm1Dls
Targeted Allele Detail

Summary

• Symbol: Pdzk1^tm1Dls
• Name: PDZ domain containing 1; targeted mutation 1, David L Silver
• MGI ID: MGI:3588076
• Synonyms: PDZK1^-
• Gene: Pdzk1 Location: Chr3:96736772-96778242 bp, + strand Genetic Position: Chr3, 42.0 cM
• Alliance: Pdzk1^tm1Dls page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100280
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, containing the ATG, and part of intron 1 were replaced by neomycin resistance cassette. Western blot of mutant liver lysates confirmed absence of protein. (J:100280)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdzk1 Mutation: 26 strains or lines available

References

• Original: J:100280 Lan D, et al., Fenofibrate induces a novel degradation pathway for scavenger receptor B-I independent of PDZK1. J Biol Chem. 2005 Jun 17;280(24):23390-6
• All: 7 reference(s)