Bace1^tm1Nn
Targeted Allele Detail

Summary

• Symbol: Bace1^tm1Nn
• Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Nobuyuki Nukina
• MGI ID: MGI:3588406
• Gene: Bace1 Location: Chr9:45749878-45775694 bp, + strand Genetic Position: Chr9, 25.22 cM
• Alliance: Bace1^tm1Nn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100272
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 1 and introduced a premature translation stop codon into the open reading frame. Successful knock down was confirmed by Northern and Western blot analyses. (J:100272)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bace1 Mutation: 30 strains or lines available

References

• Original: J:100272 Wong HK, et al., beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J Biol Chem. 2005 Jun 17;280(24):23009-17
• All: 1 reference(s)