Afmid^tm1Vnd
Targeted Allele Detail

Summary

• Symbol: Afmid^tm1Vnd
• Name: arylformamidase; targeted mutation 1, Vasily N Dobrovolsky
• MGI ID: MGI:3588407
• Gene: Afmid Location: Chr11:117716750-117730734 bp, + strand Genetic Position: Chr11, 82.96 cM, cytoband E2
• Alliance: Afmid^tm1Vnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100247
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette was inserted and replaced the 5' promoter region, first exon and part of intron 1 of Afmid. The construct also replaced the 5' promoter region, first exon, first intron and a portion of exon 2 of Tk1. Afmid mRNA was not detected in mutant liver, kidney and salivary gland. (J:100247)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Afmid Mutation: 37 strains or lines available

References

• Original: J:100247 Dobrovolsky VN, et al., Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype. Biochim Biophys Acta. 2005 Jun 20;1724(1-2):163-72
• All: 2 reference(s)