Cyp8b1^tm1Rus
Targeted Allele Detail

Summary

• Symbol: Cyp8b1^tm1Rus
• Name: cytochrome P450, family 8, subfamily b, polypeptide 1; targeted mutation 1, David Russell
• MGI ID: MGI:3588415
• Synonyms: Cyp8b1^-
• Gene: Cyp8b1 Location: Chr9:121743422-121745371 bp, - strand Genetic Position: Chr9, 72.73 cM, cytoband F4
• Alliance: Cyp8b1^tm1Rus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100206
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was replaced with beta-galactosidase coding sequence and a neomycin resistance gene in reverse orientation. Transcript was not detected in livers of mutant mice. (J:100206)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp8b1 Mutation: 33 strains or lines available

References

• Original: J:100206 Li-Hawkins J, et al., Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. J Clin Invest. 2002 Oct;110(8):1191-200
• All: 6 reference(s)