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Tg(Gnrh1-Fgfr1)1Tsai
Transgene Detail
Summary
Symbol: Tg(Gnrh1-Fgfr1)1Tsai
Name: transgene insertion 1, Pei-San Tsai
MGI ID: MGI:3588566
Synonyms: dnFGFR, G-FGFRm-1
Transgene: Tg(Gnrh1-Fgfr1)1Tsai  Location: unknown  
Alliance: Tg(Gnrh1-Fgfr1)1Tsai page
Transgene
origin
Strain of Origin:  (C57BL/6J x DBA/2J)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Gnrh1-Fgfr1)1Tsai expresses 1 gene
 
Mutation detailsA truncated form of Fgfr1 lacking the intracellular tyrosine kinase domain was ligated downstream of the rabbit beta-globin intron and placed under the control of the rat Gnrh1 promoter/enhancer region. The human growth hormone polyA sequence was inserted at the 3' end of the Fgfr1 cDNA. A transcript of approximately 1.5 kb was present only in the forebrain, where Gnhr1 neurons reside, corresponding to the size of the mutant Fgfr1. Expression was not found in the hindbrain or liver. (J:95057)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Another founder line, G-FGFRm-5, was also established, but two different transgene derived transcripts were detected. Expression of these transcripts were also detected in hindbrain as well as in the forebrain. The G-FGFRm-5 line was not studied further.
References
Original:  J:95057 Tsai PS, et al., Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population. Mol Endocrinol. 2005 Jan;19(1):225-36
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory