Sit1^tm1Lsmn
Targeted Allele Detail

Summary

• Symbol: Sit1^tm1Lsmn
• Name: suppression inducing transmembrane adaptor 1; targeted mutation 1, Luca Simeoni
• MGI ID: MGI:3588572
• Synonyms: SIT^-
• Gene: Sit1 Location: Chr4:43482083-43483709 bp, - strand Genetic Position: Chr4, 23.04 cM
• Alliance: Sit1^tm1Lsmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100408
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence was replaced with a neomycin resistance cassette. Western blot confirmed successful targeting in mutants and ablation of translation. (J:100408)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sit1 Mutation: 15 strains or lines available

References

• Original: J:100408 Simeoni L, et al., The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions. Mol Cell Biol. 2005 Sep;25(17):7557-68
• All: 4 reference(s)