Mus81^tm1Chmg
Targeted Allele Detail

Summary

• Symbol: Mus81^tm1Chmg
• Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1, Clare H McGowan
• MGI ID: MGI:3588581
• Synonyms: Mus81^-
• Gene: Mus81 Location: Chr19:5532589-5538461 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Mus81^tm1Chmg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100407
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Cre mediated excision was used to remove exons 9-12, which includes the endonuclease domain. (J:100407)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mus81 Mutation: 31 strains or lines available

References

• Original: J:100407 Dendouga N, et al., Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol Cell Biol. 2005 Sep;25(17):7569-79
• All: 6 reference(s)