Msq1^SJL/J
QTL Variant Detail

Summary

• QTL variant: Msq1^SJL/J
• Name: MAV-1 susceptibility QTL 1; SJL/J
• MGI ID: MGI:3588682
• QTL: Msq1 Location: Chr15:63389646-81086436 bp Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: SJL/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:100361

Linkage analysis was performed on 192 (BALB/cJ x SJL/J)F1 x BALB/cJ backcross animals to identify QTL associated with susceptibility to mouse adenovirus type 1 (MAV-1). Parental strain SJL/J is highly susceptible to infection with MAV-1 whereas parental strain BALB/cJ is resistant. 65 polymorphic markers at an average spacing of 19.1 cM were used for the genome scan.

Highly significant linkage to MAV-1 susceptibility mapped to mouse Chromosome 15 between 28.4 cM (D15Mit270) and 47.7 cM (D15Mit70) with LOD=21.2. This locus is named Msq1 (MAV-1 susceptibility QTL 1). The 2-LOD support interval for Msq1 spans from 39 cM to 54 cM, which corresponds to 65 Mb to 78 Mb on the physical map. Potential candidate genes mapping to the Msq1 interval include the Ly6 complex (42.7 cM), Hsf1 (43 cM), and Sla (37.5 cM).

Suggestive linkage to MAV-1 susceptibility was detected on mouse Chromosome 5 with LOD=1.2. This locus had an additive effect. Suggestive interaction between loci on mouse Chromosomes 2 and 4 was detected. Suggestive evidence of sex and genotype interaction was detected on mouse Chromosomes 4, 8, 13, and 14.

References

• Original: J:100361 Welton AR, et al., Identification of quantitative trait loci for susceptibility to mouse adenovirus type 1. J Virol. 2005 Sep;79(17):11517-22
• All: 1 reference(s)