Cd4vts1^DBA/2
QTL Variant Detail

Summary

• QTL variant: Cd4vts1^DBA/2
• Name: CD4 virgin T cell subset 1; DBA/2
• MGI ID: MGI:3589136
• QTL: Cd4vts1 Location: Chr4:102428838-102429037 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 46.99 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased proportion of virgin CD4 T cells in 8 month old virgin mice compared to C3H. (J:83220)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83220

Interval mapping was performed on a (BALB/c x C57BL/6)F1 x (C3H x DBA/2)F1 cross to identify QTLs affecting the level of T cell subsets in virgin and mated animals at 8 and 18 months of age. A QTL associated with CD4 T cell subset levels, Cd4ts2, mapped to 37.7 cM (D4Mit84) on mouse Chromosome 4 and a QTL associated with CD4 virgin T cell subset levels, Cd4vts1, mapped to 49.3 cM (D4Mit155) on mouse Chromosome 4 with statistical significance of P<0.05. Cd4ts2 is associated with CD4 T cell levels in 8 month old mated mice. Cd4vts1 is associated with CD4 virgin T cell levels in 8 month old virgin mice.

References

• Original: J:83220 Jackson AU, et al., Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun. 2003 Jan;4(1):30-9
• All: 1 reference(s)