Cd8ts3^C3H
QTL Variant Detail

Summary

• QTL variant: Cd8ts3^C3H
• Name: CD8 T cell subset 3; C3H
• MGI ID: MGI:3589157
• QTL: Cd8ts3 Location: Chr15:51004694-51004804 bp Genetic Position: Chr15, cM position of peak correlated region/allele: 19.26 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased proportion of CD8 T cells in 8 month old virgin mice compared to DBA/2. (J:83220)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83220

Interval mapping was performed on a (BALB/c x C57BL/6)F1 x (C3H x DBA/2)F1 cross to identify QTLs affecting the level of T cell subsets in virgin and mated animals at 8 and 18 months of age. A QTL associated with CD8 T cell subset levels, Cd8ts3, mapped to 21 cM (D15Mit100) on mouse Chromosome 15 with statistical significance of P<0.05. Cd8ts3 is associated with CD8 T cell levels and CD4 T cell levels in 8 month old virgin mice.

References

• Original: J:83220 Jackson AU, et al., Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun. 2003 Jan;4(1):30-9
• All: 1 reference(s)