Bax^tm2Sjk
Targeted Allele Detail

Summary

• Symbol: Bax^tm2Sjk
• Name: BCL2-associated X protein; targeted mutation 2, Stanley J Korsmeyer
• MGI ID: MGI:3589203
• Synonyms: Bax^fl
• Gene: Bax Location: Chr7:45111121-45116322 bp, - strand Genetic Position: Chr7, 29.32 cM, cytoband B5
• Alliance: Bax^tm2Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100463
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 2-4. A loxP-flanked neo was removed via cre-mediated recombination. (J:100463)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bax Mutation: 24 strains or lines available

References

• Original: J:100463 Takeuchi O, et al., Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11272-7
• All: 96 reference(s)