Bcl2l11^tm1Sjk
Targeted Allele Detail

Summary

• Symbol: Bcl2l11^tm1Sjk
• Name: BCL2 like 11; targeted mutation 1, Stanley J Korsmeyer
• MGI ID: MGI:3589204
• Synonyms: Bim^-
• Gene: Bcl2l11 Location: Chr2:127967958-128004467 bp, + strand Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
• Alliance: Bcl2l11^tm1Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100463
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The first four exons were deleted via homologous recombination. Lack of aberrant protein was confirmed in mutant ES cells. This allele was generate from Bcl2l11^tm2Sjk. (J:100463)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l11 Mutation: 36 strains or lines available

References

• Original: J:100463 Takeuchi O, et al., Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11272-7
• All: 10 reference(s)