Rhoc^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Rhoc^tm1Mak
• Name: ras homolog family member C; targeted mutation 1, Tak W Mak
• MGI ID: MGI:3589206
• Synonyms: RhoC^-, RhoC^delta2-3
• Gene: Rhoc Location: Chr3:104696350-104701775 bp, + strand Genetic Position: Chr3, 45.86 cM
• Alliance: Rhoc^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100482
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated deletion of exons 2 and 3 caused termination codons in all three reading frames and removed 70% of the protein sequence. Northern blot of mutant MEFs confirmed the creation of a null allele. (J:100482)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rhoc Mutation: 18 strains or lines available

References

• Original: J:100482 Hakem A, et al., RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev. 2005 Sep 1;19(17):1974-9
• All: 4 reference(s)