Apc^tm1Kk
Targeted Allele Detail

Summary

• Symbol: Apc^tm1Kk
• Name: APC, WNT signaling pathway regulator; targeted mutation 1, Khashayarsha Khazaie
• MGI ID: MGI:3589207
• Synonyms: Apc^lox468
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm1Kk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100461
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 11 and 12. Cre-mediated deletion of these exons would result in the out-of-frame splicing of exon 10 to exon 13 and the generation of a prematurely terminated 468-amino acid protein. This mutant protein would be shorter than most truncated Apc proteins. (J:100461)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:100461 Gounari F, et al., Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat Immunol. 2005 Aug;6(8):800-9
• All: 18 reference(s)