Dicer1^tm1.1Bdh
Targeted Allele Detail

Summary

• Symbol: Dicer1^tm1.1Bdh
• Name: dicer 1, ribonuclease type III; targeted mutation 1.1, Brian D Harfe
• MGI ID: MGI:3589209
• Synonyms: Dicer^floxdelta, Diver^delta
• Gene: Dicer1 Location: Chr12:104654001-104718211 bp, - strand Genetic Position: Chr12, 54.83 cM, cytoband E-F1
• Alliance: Dicer1^tm1.1Bdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100475
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Crossing Dicer1^tm1Bdh mice with mice expressing cre in the germline resulted in the loss of the exon encoding most of the second RNaseIII domain. (J:100475)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dicer1 Mutation: 96 strains or lines available

References

• Original: J:100475 Harfe BD, et al., The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10898-903
• All: 13 reference(s)