Peg3^tm1Masu
Targeted Allele Detail

Summary

• Symbol: Peg3^tm1Masu
• Name: paternally expressed 3; targeted mutation 1, M A Surani
• MGI ID: MGI:3589260
• Synonyms: Peg^-
• Gene: Peg3 Location: Chr7:6706891-6733430 bp, - strand Genetic Position: Chr7, 3.89 cM, cytoband A2-B1
• Alliance: Peg3^tm1Masu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54324
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A beta-geo cassette was inserted into exon 5. Northern blot of embryos with the paternally inherited allele failed to detect wild-type transcript, however, appropriate beta-gal expression was demonstrated in the brain, pituitary and adrenal medulla of adults. Extended exposure of blots revealed a weak signal corresponding to an aberrant alternatively spliced transcript involving exon 4, 49 nucleotides from beta-geo and exon 6. Mutants with the maternally inherited allele failed to detect beta-gal activity as expected. (J:54324)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Peg3 Mutation: 61 strains or lines available

References

• Original: J:54324 Li L, et al., Regulation of maternal behavior and offspring growth by paternally expressed Peg3. Science. 1999 Apr 9;284(5412):330-3
• All: 7 reference(s)