Gcnt2^tm1Tmu
Targeted Allele Detail

Summary

• Symbol: Gcnt2^tm1Tmu
• Name: glucosaminyl (N-acetyl) transferase 2 (I blood group); targeted mutation 1, Takashi Muramatsu
• MGI ID: MGI:3589370
• Synonyms: Ignt^-
• Gene: Gcnt2 Location: Chr13:41013417-41114368 bp, + strand Genetic Position: Chr13, 20.12 cM, cytoband A5
• Alliance: Gcnt2^tm1Tmu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100533
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 2.0-kb portion of exon 3 sequence encoding the catalytic domain common to all three splice variants was deleted via homologous recombination. Northern blot failed to detect transcript in livers from mutant mice. RT-PCR failed to detect transcript in cerebellum and kidney samples from mutants. (J:100533)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gcnt2 Mutation: 88 strains or lines available

References

• Original: J:100533 Chen GY, et al., Abnormalities caused by carbohydrate alterations in Ibeta6-N-acetylglucosaminyltransferase-deficient mice. Mol Cell Biol. 2005 Sep;25(17):7828-38
• All: 1 reference(s)