Gpx4^tm1Marc
Targeted Allele Detail

Summary

• Symbol: Gpx4^tm1Marc
• Name: glutathione peroxidase 4; targeted mutation 1, Marcus Conrad
• MGI ID: MGI:3589378
• Synonyms: nPHGPx^-
• Gene: Gpx4 Location: Chr10:79883000-79892273 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gpx4^tm1Marc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100525
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The EGFP gene replaced most of the coding region of the alternative first exon. A translational stop cassette ws inserted downstream of EGFP. In situ hybridization confirmed the absence of expression in mutant testis. Wesetern blot failed to detect the nuclear protein form in mutants. (J:100525)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpx4 Mutation: 82 strains or lines available

References

• Original: J:100525 Conrad M, et al., The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability. Mol Cell Biol. 2005 Sep;25(17):7637-44
• All: 1 reference(s)