About   Help   FAQ
Rigitm1Aki
Targeted Allele Detail
Summary
Symbol: Rigitm1Aki
Name: RNA sensor RIG-I; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3589395
Synonyms: Ddx58-, RIG-I-, RIGI-
Gene: Rigi  Location: Chr4:40203773-40239828 bp, - strand  Genetic Position: Chr4, 20.24 cM
Alliance: Rigitm1Aki page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100539
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace a 3.6 kb fragment encoding the ORF, exons 8-10, with a neomycin resistance gene and HSV-TK driven by the PGK promoter. Northern blot and Western blot of MEFs confirmed absence of transcript and protein, respectively. (J:100539)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rigi Mutation:  55 strains or lines available
References
Original:  J:100539 Kato H, et al., Cell type-specific involvement of RIG-I in antiviral response. Immunity. 2005 Jul;23(1):19-28
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory