Rigi^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Rigi^tm1Aki
• Name: RNA sensor RIG-I; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3589395
• Synonyms: Ddx58^-, RIG-I^-, RIGI^-
• Gene: Rigi Location: Chr4:40203773-40239828 bp, - strand Genetic Position: Chr4, 20.24 cM
• Alliance: Rigi^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100539
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace a 3.6 kb fragment encoding the ORF, exons 8-10, with a neomycin resistance gene and HSV-TK driven by the PGK promoter. Northern blot and Western blot of MEFs confirmed absence of transcript and protein, respectively. (J:100539)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rigi Mutation: 55 strains or lines available

References

• Original: J:100539 Kato H, et al., Cell type-specific involvement of RIG-I in antiviral response. Immunity. 2005 Jul;23(1):19-28
• All: 36 reference(s)