Cflar^tm1Ywh
Targeted Allele Detail

Summary

• Symbol: Cflar^tm1Ywh
• Name: CASP8 and FADD-like apoptosis regulator; targeted mutation 1, You-Weh He
• MGI ID: MGI:3589399
• Synonyms: cflip^f, c-FLIP^f
• Gene: Cflar Location: Chr1:58750667-58798043 bp, + strand Genetic Position: Chr1, 29.16 cM
• Alliance: Cflar^tm1Ywh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100558
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites flanking exon 1, which encodes amino acids 1-98. An FRT-flanked neo cassette was included in the vector and subsequently removed by crossing with mice expressing Flp reocmbinase. (J:100558)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cflar Mutation: 32 strains or lines available

References

• Original: J:100558 Zhang N, et al., An essential role for c-FLIP in the efficient development of mature T lymphocytes. J Exp Med. 2005 Aug 1;202(3):395-404
• All: 21 reference(s)