Etv5^tm1Kmm
Targeted Allele Detail

Summary

• Symbol: Etv5^tm1Kmm
• Name: ets variant 5; targeted mutation 1, Kenneth M Murphy
• MGI ID: MGI:3589421
• Synonyms: ERM^-, Etv5^-
• Gene: Etv5 Location: Chr16:22200063-22258320 bp, - strand Genetic Position: Chr16, 13.3 cM, cytoband B1
• Alliance: Etv5^tm1Kmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100645
• Parent Cell Line: MC50 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-5, which encode the initiation codon and transcriptional activation domain, were replaced with a floxed neo cassette. Transient cre expression removed the neo in two clones: A7 and E7. Northern blot of brain samples failed to detect full-length transcript. (J:100645)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Etv5 Mutation: 271 strains or lines available

References

• Original: J:100645 Chen C, et al., ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature. 2005 Aug 18;436(7053):1030-4
• All: 13 reference(s)