Ndel1^tm2Shr
Targeted Allele Detail

Summary

• Symbol: Ndel1^tm2Shr
• Name: nudE neurodevelopment protein 1 like 1; targeted mutation 2, Shinji Hirotsune
• MGI ID: MGI:3589467
• Synonyms: Ndel1^cko, Ndel1^cko(IV)
• Gene: Ndel1 Location: Chr11:68712260-68743961 bp, - strand Genetic Position: Chr11, 42.09 cM
• Alliance: Ndel1^tm2Shr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100552
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites to flank exon IV. A floxed neo was included in the vector. This allele acts as a hypomorph with expression suppressed to 30%. (J:100552)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ndel1 Mutation: 40 strains or lines available

References

• Original: J:100552 Sasaki S, et al., Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol Cell Biol. 2005 Sep;25(17):7812-27
• All: 5 reference(s)