Tg(PRNP-APPSweInd)8Dwst
Transgene Detail
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Symbol: |
Tg(PRNP-APPSweInd)8Dwst |
Name: |
transgene insertion 8, David Westaway |
MGI ID: |
MGI:3589475 |
Synonyms: |
APP-KM670/671NL+V717F, CRND8, Tg19959, Tg(APPSwInd)8Dwst, TgCRND8, Tg(PRNP-APP*Swe*Ind)8Dwst |
Transgene: |
Tg(PRNP-APPSweInd)8Dwst Location: unknown
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Alliance: |
Tg(PRNP-APPSweInd)8Dwst page
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Increase in creatine deposits in hippocampus of Tg(PRNP-APPSweInd)8Dwst/0 mice with age
Show the 2 phenotype image(s) involving this allele.
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(PRNP-APPSweInd)8Dwst expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APP (351) |
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The gene encodes for the Swedish and Indiana mutations. |
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Mutation details: The transgene expresses the mutant human amyloid protein precursor APPSweInd, which bears both the Swedish (K670N/M671L) and the Indiana (V717F) mutations, under the control of the Syrian hamster prion protein promoter. Transgenic mice express the App protein in brain at approximately 5 times the level of control mice. High level production of the pathogenic Abeta42 form of the Abeta peptide is seen by three months of age.
(J:69967)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:69967 Chishti MA, et al., Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem. 2001 Jun 15;276(24):21562-70 |
All: |
173 reference(s) |
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