Sox2^tm1Lpev
Targeted Allele Detail

Summary

• Symbol: Sox2^tm1Lpev
• Name: SRY (sex determining region Y)-box 2; targeted mutation 1, Larysa Pevny
• MGI ID: MGI:3589809
• Synonyms: SOX2-EGFP, Sox2-GFP
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^tm1Lpev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99497
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced by the coding sequence for enhanced green fluorescent protein. Fluorescence was detected in neurogenic and nonneurogenic regions in the postnatal and adult CNS. (J:99497)

Expression

In Mice Carrying this Mutation:	54 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Sox2^tm1Lpev

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:99497 Ellis P, et al., SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. Dev Neurosci. 2004 Mar-Aug;26(2-4):148-65
• All: 42 reference(s)