Trp53^tm1Thl
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Thl
• Name: transformation related protein 53; targeted mutation 1, Thomas Ludwig
• MGI ID: MGI:3589921
• Synonyms: p53^flex7, Trp53^loxP, Trp53^tm1Ppp
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Thl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100683
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• A targeting construct was designed to insert loxP sites to flank exon 7. (J:100683)

Disease models

Expression

In Mice Carrying this Mutation:

52024 assay results 1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1Thl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:100683 Chen Z, et al., Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature. 2005 Aug 4;436(7051):725-30
• All: 27 reference(s)