Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Transgene Detail
|
Symbol: |
Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell |
Name: |
transgene insertion N8, John F Elliott |
MGI ID: |
MGI:3590083 |
Synonyms: |
DQ6 transgene, HLA-DQ6 transgene, Tg(CD4,HLA-DQA1*0102,HLADQB1*0602)1Ell |
Transgene: |
Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell Location: unknown
|
Alliance: |
Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell page
|
|
|
Transgene Type: |
|
Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell expresses
3 genes
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
CD4 (920) |
|
|
human |
HLA-DQA1 (3117) |
|
|
human |
HLA-DQB1 (3119) |
|
|
|
|
|
Mutation details: The human CD4 gene lacking one exon but including its promoter was fused downstream of a mouse CD4 enhancer element then mixed with a large DNA fragment containing both HLA-DQA*0102 and HLA-DQB*0602 and injected into NOD/LtJ one celled embryos. A single founder line is maintained.
(J:113267)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:113267 Hayward SL, et al., CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J Immunol. 2006 Jun 15;176(12):7715-25 |
All: |
3 reference(s) |
|