Ccdc62^repro29
Chemically induced Allele Detail

Summary

• Symbol: Ccdc62^repro29
• Name: coiled-coil domain containing 62; reproductive mutant 29, JAX Reproductive Mutagenisis Program
• MGI ID: MGI:3590192
• Synonyms: G1-485-3
• Gene: Ccdc62 Location: Chr5:124068683-124107958 bp, + strand Genetic Position: Chr5, 63.28 cM
• Alliance: Ccdc62^repro29 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis created a C>T point mutation in exon 6, changing arginine codon CGA to stop codon TGA (p.Arg284Stop or p.R284*) in the highly conserved second coiled-coil domain. Western blot analysis showed the expression of a truncated peptide from this allele and qRT-PCR showed a significant reduction of mRNA expression from the allele in testes. (J:244081)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccdc62 Mutation: 16 strains or lines available

References

• Original: J:92463 JAX Reproductive Mutagenesis Program, Heritable mouse mutants from The Jackson Laboratory Reproductive Genomics Mutagenesis Program. MGI Direct Data Submission. 2004-7
• All: 2 reference(s)