Hmgn1^tm1Mbus
Targeted Allele Detail

Summary

• Symbol: Hmgn1^tm1Mbus
• Name: high mobility group nucleosomal binding domain 1; targeted mutation 1, Michael Bustin
• MGI ID: MGI:3590648
• Synonyms: Hmgn1^-, Hmgn1^tm1
• Gene: Hmgn1 Location: Chr16:95922788-95928925 bp, - strand Genetic Position: Chr16, 56.83 cM
• Alliance: Hmgn1^tm1Mbus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100282
• Parent Cell Line: ESVJ-1183 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 2, 3 and part of 4 were replaced with a neomycin resistance cassette. Western blot of mutant MEFs confirmed absence of protein. Heterozygotes expressed approximately half of that detected in wild-type cells. (J:100282)

Generation of the Hmgn1^tm1Mbus allele

Expression

In Mice Carrying this Mutation:	7 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hmgn1 Mutation: 12 strains or lines available

References

• Original: J:100282 Birger Y, et al., Chromosomal protein HMGN1 enhances the rate of DNA repair in chromatin. EMBO J. 2003 Apr 1;22(7):1665-75
• All: 20 reference(s)