Dkk2^tm1Dwu
Targeted Allele Detail

Summary

• Symbol: Dkk2^tm1Dwu
• Name: dickkopf WNT signaling pathway inhibitor 2; targeted mutation 1, Dianqing Wu
• MGI ID: MGI:3590649
• Synonyms: Dkk2^-
• Gene: Dkk2 Location: Chr3:131791053-131886065 bp, + strand Genetic Position: Chr3, 61.32 cM, cytoband H2
• Alliance: Dkk2^tm1Dwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100858
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the four coding exons via homologous recombination. RT-PCR failed to detect transcript in mutant bone marrow stromal osteoblasts, and western blot confirmed absence of protein in mutants. (J:100858)

Expression

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dkk2 Mutation: 26 strains or lines available

References

• Original: J:100858 Li X, et al., Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet. 2005 Sep;37(9):945-52
• All: 10 reference(s)