Tg(Eno2-PSEN1*P117L)1Gae
Transgene Detail

Summary

• Symbol: Tg(Eno2-PSEN1*P117L)1Gae
• Name: transgene insertion 1, Gregory A Elder
• MGI ID: MGI:3590651
• Synonyms: FAD Tg, P117L Tg
• Transgene: Tg(Eno2-PSEN1*P117L)1Gae Location: unknown
• Alliance: Tg(Eno2-PSEN1*P117L)1Gae page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-PSEN1*P117L)1Gae expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

  Transgene codes for a protein with a proline to leucine mutation.

• Mutation details: The rat enolase 2, gamma promoter was used to drive expression of human presenilin 1 with the P117L mutation in neuronal cells. The mutation is located in the predicted small cytoplasmic loop between the TM1 and TM2 domains. Western blot demonstrated that expression of protein from the transgene was two to three times higher than expression of the endogenous mouse Psen1. Widespread and essentially neuron specific expression was confirmed by in situ hybridization and immunohistochemistry. (J:100959)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100959 Wen PH, et al., Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiol Dis. 2002 Jun;10(1):8-19
• All: 2 reference(s)