Mapt^tm2Arbr
Targeted Allele Detail

Summary

• Symbol: Mapt^tm2Arbr
• Name: microtubule-associated protein tau; targeted mutation 2, Silvia Arber
• MGI ID: MGI:3590682
• Synonyms: Tau^f(mGFP), Tau-GFP-nlsLacZ, Tau-loxp-STOP-lox-mGFP-IRES-NLS-LacZ, Tau^{loxP-stop-loxP-MARCKSeGFP-IRES-nlslacZ}, Tau^{lox-STOP-lox-FLP-INLA}, Tau^{Lox-STOP-Lox-mGFP-IRESnlsLacZ}, Tau^LSL-mEGFP, Tau:lxp-stp-lxp:mGFP-inLZ, Tau-mEGFP-LacZ, Tau^mGFP, Tau^mGFP-INLA, Tau^mGFP-nlacZ, Tau^mGFP_nlacZ, Tau-nLacZ, TauR
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm2Arbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100886
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing loxP-STOP-loxP-mGFP-IRES-NLS-lacZ-pA was inserted into exon 2 of the locus. mGFP consists of the first 40 amino acids of the protein MARCKS, a plasmalemmal targeting sequence, fused to enhanced GFP (eGFP). (J:100886, J:154023)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 430 strains or lines available

References

• Original: J:100886 Hippenmeyer S, et al., A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol. 2005 May;3(5):e159
• All: 140 reference(s)