Kit^tm1Bpr
Targeted Allele Detail

Summary

• Symbol: Kit^tm1Bpr
• Name: KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1, Brian P Rubin
• MGI ID: MGI:3603004
• Synonyms: Kit^K641E:Neo
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^tm1Bpr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100778
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Insertion
• Mutation details: A targeting construct was designed to introduce a lysine to glutamic acid mutation at amino acid position 641 (K641E) in exon 13. A loxP flanked neomycin resistance gene was included in the targeting vector in intron 13. Position 641 is within the first portion of the slpit kinase domain. (J:100778)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 182 strains or lines available

References

• Original: J:100778 Rubin BP, et al., A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E. Cancer Res. 2005 Aug 1;65(15):6631-9
• All: 3 reference(s)