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Sil1Gt(RST462)Byg
Gene trapped Allele Detail
Summary
Symbol: Sil1Gt(RST462)Byg
Name: SIL1 nucleotide exchange factor; gene trap RST462, BayGenomics
MGI ID: MGI:3603007
Synonyms: Sil1Gt, Sil1Gt(pGT2TMpfa)1Slac
Gene: Sil1  Location: Chr18:35399449-35632443 bp, - strand  Genetic Position: Chr18, 18.97 cM
Alliance: Sil1Gt(RST462)Byg page
Mutation
origin
Mutant Cell Line:  RST462
Germline Transmission:  Earliest citation of germline transmission: J:100860
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT2TMpfa     Vector Type: secretory trap
 
Mutation detailsThe gene trap vector pGT2TMpfa integrated into the locus resulting in the truncation of transcripts after exon 7. (J:100860)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sil1 Mutation:  27 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:100860 Zhao L, et al., Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP. Nat Genet. 2005 Sep;37(9):974-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory