Tagap^tm1Bgh
Targeted Allele Detail

Summary

• Symbol: Tagap^tm1Bgh
• Name: T cell activation Rho GTPase activating protein; targeted mutation 1, Bernhard G Herrmann
• MGI ID: MGI:3603008
• Synonyms: Tagap1^tm3Bgh
• Gene: Tagap Location: Chr17:8144832-8153729 bp, + strand Genetic Position: Chr17, 4.82 cM
• Alliance: Tagap^tm1Bgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100859
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 5. The resulting transcript is predicted to be truncated upstream of the RhoGAP domain. Mutant testis analyzed by RT-PCR failed to detect transcript. (J:100859)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tagap Mutation: 22 strains or lines available

References

• Original: J:100859 Bauer H, et al., The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice. Nat Genet. 2005 Sep;37(9):969-73
• All: 3 reference(s)