Lbx1^tm2Cbm
Targeted Allele Detail

Summary

• Symbol: Lbx1^tm2Cbm
• Name: ladybird homeobox 1; targeted mutation 2, Carmen Birchmeier
• MGI ID: MGI:3603145
• Synonyms: Lbx1^GFP
• Gene: Lbx1 Location: Chr19:45221123-45224251 bp, - strand Genetic Position: Chr19, 38.61 cM, cytoband D
• Alliance: Lbx1^tm2Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100909
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting construct was designed to insert a GFP at the initiation codon. A frame shift was introduced into exon 2, which encodes the Lbx1 homeodomain. GFP was expressed in migrating muscle progeitors of the dorsal and ventral limb in a pattern similar to the endogenous protein. (J:100909)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lbx1 Mutation: 13 strains or lines available

References

• Original: J:100909 Vasyutina E, et al., CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev. 2005 Sep 15;19(18):2187-98
• All: 3 reference(s)