Mef2c^tm1Jjs
Targeted Allele Detail

Summary

• Symbol: Mef2c^tm1Jjs
• Name: myocyte enhancer factor 2C; targeted mutation 1, John J Schwarz
• MGI ID: MGI:3603182
• Synonyms: Mef2c^flox, Mef2c^loxP
• Gene: Mef2c Location: Chr13:83652153-83815199 bp, + strand Genetic Position: Chr13, 43.68 cM
• Alliance: Mef2c^tm1Jjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100949
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector consists of a loxP site inserted upstream of exon 2, a second loxP site inserted downstream of exon 2 followed by a FRT-flanked neomycin cassette . Flp mediated recombination removed the neomycin cassette. (J:100949)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mef2c Mutation: 34 strains or lines available

References

• Original: J:100949 Vong LH, et al., Generation of conditional Mef2cloxP/loxP mice for temporal- and tissue-specific analyses. Genesis. 2005 Sep;43(1):43-8
• All: 24 reference(s)